|
KMID : 1036720150480040299
|
|
Journal of Nutrition and Health
2015 Volume.48 No. 4 p.299 ~ p.309
|
|
|
Effects of the C3G/D3G anthocyanins-rich black soybean testa extracts on improvement of lipid profiles in STZ-induced diabetic rats
|
|
Park So-Young
Park Su-Jeong
Kang Song-Jooo
Kim Na-Young
Kim Da-Saem
Kim Min-Jin
Kim Seon-Ah
Kim Ji-Young
Park So-Yeon
Park So-Hyun
Youn Cho-Rong
Lee Bo-Ram
Lee Hyo-Eun
Choi So-Young
Choi Hee-Won
Heo Jin-Yeo
Hwang A-Yeong
Lee Myoung-Sook
|
|
|
Abstract
|
|
|
Purpose: The purpose of this study was to examine the effect of black soybean (CJ-3) testa extracts on lipid profiles in streptozotocin (STZ)-induced diabetic rats.
Methods: One control group and four STZ-induced diabetic groups with different doses of black soybean (CJ-3) testa extracts treatment [0 mg/kg (diabetic control, EX), 250 mg/kg (EX-250), 500 mg/kg (EX-500), 1,000 mg/kg (EX-1000)] were orally administered for 4 weeks.
Results: All CJ-3 treatment groups had remarkably lower serum triglyceride (TG) levels than that of EX group (p < 0.05) whereas hepatic TG contents did not show any differences. Results from serum total cholesterol (TC) concentrations of EX-250 and EX-1000 groups were decreased compared to EX group (p < 0.05). Furthermore, protein levels of 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase from the liver decreased in all treatment groups (p < 0.05). However, significant differences were not observed in serum glucose and insulin, and glucose transporter 4 (GLUT-4) protein expression in skeletal muscle tissue.
Conclusion: These results suggest that black soybean testa extracts could be useful for improvement of hyperlipidemia and hypercholesteremia in diabetes.
|
|
|
KEYWORD
|
|
|
anthocyanin, black soybean testa, lipid profiles, streptozotocin, diabetes
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|